Hi Dr. Huang, thank you for the article. Do the eggs from the dominant follicles tend to be 'better' (morphologically, chromosomally after maturation, etc.) than the others? (Not sure how we could determine this - maybe with COS studies where stimulation occurs after the dominant follicle is identified, and eggs are retrieved at different times based on maturity?)
Also, is it true that the body tends to recruit 'good' eggs as contenders for ovulation each month?
As someone with high ovarian reserve markers, I know that I'm fortunate to have a large pool of high-quality eggs left. However, I'm trying to figure out what that means in practicality if I were to decide to conceive naturally. Am I ovulating better-quality eggs than someone my age with a much lower ovarian reserve? Or if my AFC is 30 and someone else's is 4, but we have the same proportion of good ones and the dominant follicle is just the one that happens to respond to the hormones best, does it even matter that I have a lot left? Is my high OR actually _worse_ for natural conception as time passes because I'm burning through my good ones rapidly? etc.
Not sure whether eggs in dominant follicles are "better" than those in atretic follicles. My personal view is that the selection of dominant follicles is random. The follicle that is the right size (to respond to gonadotropin) at the right time thrive. Whereas, those either not the right size and/or not at the right time become atretic.
High ovarian reserve usually is associated with PCOS. The CONC of PCOS is needing ovulation induction if trying to conceive naturally, the PRO of PCOS is many eggs available for IVF.
Hello. I appreciate your substack and have myself been helping women get pregnant, stay pregnant and have healthy babies both in my clinic and online telemedicine for over 30 years. Please note many articles I've written sharing how to boos fertility and hormones naturally with over 30 years of clinical experience: https://fertilitywhisperer.substack.com/
Please consider sharing my substack with your readers as I have yours, as our mutual aim is to help women conceive naturally and have healthy babies. Dr. Shasta Ericson DAOM www.fertilitywhisperer.com
Hi Dr. Huang, thank you for the article. Do the eggs from the dominant follicles tend to be 'better' (morphologically, chromosomally after maturation, etc.) than the others? (Not sure how we could determine this - maybe with COS studies where stimulation occurs after the dominant follicle is identified, and eggs are retrieved at different times based on maturity?)
Also, is it true that the body tends to recruit 'good' eggs as contenders for ovulation each month?
As someone with high ovarian reserve markers, I know that I'm fortunate to have a large pool of high-quality eggs left. However, I'm trying to figure out what that means in practicality if I were to decide to conceive naturally. Am I ovulating better-quality eggs than someone my age with a much lower ovarian reserve? Or if my AFC is 30 and someone else's is 4, but we have the same proportion of good ones and the dominant follicle is just the one that happens to respond to the hormones best, does it even matter that I have a lot left? Is my high OR actually _worse_ for natural conception as time passes because I'm burning through my good ones rapidly? etc.
Not sure whether eggs in dominant follicles are "better" than those in atretic follicles. My personal view is that the selection of dominant follicles is random. The follicle that is the right size (to respond to gonadotropin) at the right time thrive. Whereas, those either not the right size and/or not at the right time become atretic.
High ovarian reserve usually is associated with PCOS. The CONC of PCOS is needing ovulation induction if trying to conceive naturally, the PRO of PCOS is many eggs available for IVF.
Thanks so much for the info! In my case, I don't have PCOS, just high OR.
Hello. I appreciate your substack and have myself been helping women get pregnant, stay pregnant and have healthy babies both in my clinic and online telemedicine for over 30 years. Please note many articles I've written sharing how to boos fertility and hormones naturally with over 30 years of clinical experience: https://fertilitywhisperer.substack.com/
Please consider sharing my substack with your readers as I have yours, as our mutual aim is to help women conceive naturally and have healthy babies. Dr. Shasta Ericson DAOM www.fertilitywhisperer.com